The woofer and tweeter are direct replacements, and they can be exchanged through the front of the baffle. The cabinet stays the same.
There are some crossover changes required, but they are inexpensive and pretty easy to do. Some resistor values are different for the DE250 because it has slightly higher voltage sensitivity than the PSD2002. You can see the components used for each option in the "Notes" section of the crossover document.
Here are some of my thoughts about the upgrades available:
For different compression drivers, is it only resistor swaps? I guess I'm wondering if the horn dictates the frequency response vs. the driver for crossover design.