Speakers with controlled directivity can really help sound quality from 200Hz up, even in troublesome rooms. And multiple subs help smooth room modes, improving sound quality at lower frequencies. So some of the problems room acoustics give us can be at least partially mitigated with the right speakers and setup.
This is the best advice but I think this is costly. How many subs would you recommend in order to have a good sound quality? Anyway, I watch movies at night and aesthetics doesn't matter to me anymore because the room is dark.