Troy,I have made both Theater 4s and 2 Towers. They are in utterly different systems (the Fours are driven by 8W, the Twos by 100W) and entirely different venues. My Twos have the old tweeters. I have tin ears. Take what I say with a pound of salt.
I love both (witness that my pre-DIY commercially-bought mega-bucks speakers have been relegated to a tertiary system), but with all those caveats, I love my Four Pis more. They are beautifully balanced and the presentation is utterly three-dimensional. I tend to value tone and integration more than dynamics or detail, but even with 8W, complex orchestral like Mahler (who demands dynamics) comes through beautifully. On the other end, I'm listening to Tom Russell's version of "El Paso" (basically vocal, acoustic guitar and harmonica) right now and each pluck of the guitar comes through beautifully. My best friend, not an audiophile, is a James Taylor / Simon & Garfunkel fan (I can take them in short bursts). He almost went into cardiac arrest (and/or had an orgasm, I couldn't figure out which) when he heard them though the Fours.
In sum, if you can handle the size of the Fours, go for them. But if you can't, you're still going to have to look far and wide to do better than the Twos.
Tell us more about your system and your musical tastes, and I'm sure the crowd here will do their best to give you further advice.
I'm not affiliated! Just a fan.