Absolutely, you can make a three-way seven π using a 22xx woofer, a 21xx midrange and a 24xx tweeter. That was the configuration of all the seven π's for many years.The seven π using a JBL 2205 used the JBL 2105 midrange, and it was an excellent speaker. You could also do this with a 2225 or 2226. Since 2105's are scarce these days, you might use a 2123 or 2012 instead.
In the 90's, I started making a lot of two-way systems. Construction is simpler and they have a certain magic. But the three-ways described above are really sweet too.