10Pi's are hard enough to move as it is. If you filled the voids with sand, you would need a crane.Maybe what you could do is fit rubber bungs in the side of the cab for the top and bottom spaces. Move the speaker into position, and then funnel the sand in. If you wanted to move them later, you might be able to tip them over (with a lot of help) and tip out the sand.
Have you got strong floors? This sort of treatment could get 10Pi's sounding even more 'solid'.