Tubes can go at anytime. I've got some in an amp that is over 35 years old and a couple are still the originals and test good. I've had others last 5 minutes that were brand new. I would suggest checking the tubes on a tester that checks for transconductance as well as emission and leakage. If the tubes check out fine, then you might be needing to replace some of the capacitors in the circuit. The electrolytics will eventually go bad and need replaced.This amp uses 4 12AX7 tubes in the preamp and 4 6L6 in the power amp correct?
Another thing you might do: Look in your manual (if you still have it)and see which tubes are for what in the preamp. You might try switching a couple around to see if you can localize a tube going bad. I've done this many times to find a microphonic tube.
And another suggestion: Peavey has a guitar amp forum on their site that you can get many, many answers from guys who would really know this amp, including some of the designers. I've had excellent luck there for my 5150. Here's a link.
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