If drivers not dead centered its not a problem. Just avoid a square OB design unless you off set driver. You might want to add some wings to your OB to keep size down and bass up. Also if baffles not massive and braced driver will slightly move it forward and back this will smear image and reduce tebile a wee bit. I like my OB set with drivers center at ear level if fullrange slightly lower with a 2 way, mid driver centered in 3 way.