Hi Scott!The 416 driver will play lower than the 2226, also requires approx 8 cu ft cab tuned to 40 hz for most applications.
Many folks like the midrange of the 416 over the 2226(Tom B. is one of them). I believe the 2226 is more linear across the bandwidth.
I also think the 416's have a "bungee-cord" type bass, but then the 2226 is already down around 60hz, but I get usable down to the upper 30's in my smallish/well damped room(12' x 16').
I tried the 416's with various crossovers, but did not do anything I liked. That's not to say that other folks would not find it worthwhile to use. I find it a personal choice thing!
If you need more opinions send me a e-mail w/phone nr.
Regards, Ron